SYSTEM FOR ELECTROPORATION OF PARTICLES
A system for cell bioprocessing and cell therapy manufacturing can include a series of microfluidic modules to enable continuous-flow end-to-end cell bioprocessing. Each module can implement a different technology, and the modules can be coupled to one another to perform various unit operations in the cell bioprocessing or cell-therapy manufacturing chain to enable direct processing of a blood or blood product sample. The system can automatically and continuously process the sample into genetically-modified lymphocytes or T cells for cellular therapy. The technologies implemented by each module in the system can include any combination of microfluidic acoustophoresis, microfluidic acoustophoretic media exchange or cell washing, and continuous-flow microfluidic electrotransfection. Modules implementing these microfluidic technologies can be interconnected with plastic tubing or with a custom manifold.
Publication date: 27/05/2021
Number: CA3159149A1 (A1)
Applicant: CHARLES STARK DRAPER LABORATORY INC?[US]
Inventor: TANDON VISHAL?[US]; BORENSTEIN JEFFREY?[US] (5)