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Chemistry of Polythiols and Their Industrial Applications

Thiols can react with readily available organic substrates under benign conditions, making them suitable for use in chemical, biological, physical, and materials and engineering research areas. In particular, the highly efficient thiol-based click reaction includes the reaction of radicals with electron-rich enes, Michael addition with electron-poor enes, carbonyl addition with isocyanate SN2 ring opening with epoxies, and SN2 nucleophilic substitution with halogens. This mini review provides insights into emerging venues for their industrial applications, especially for the applications of thiol-ene, thiol–isocyanate, and thiol–epoxy reactions, highlighting a brief chemistry of thiols as well as various approaches to polythiol synthesis.

Publication date: 14/03/2024

Author: Hong

Reference: doi: 10.3390/ma17061343

MDPI (materials)


This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 870292.