Technological watch

Collagen?cellulose?poly(l?lactide) scaffold by electrospinning and plasma?assisting fabrication for bone tissue engineering applications

Collagen?cellulose?poly(l?lactide) scaffold fabricated by electrospinning and radiofrequency plasma treatment increased physicochemical properties and cell attachment for bone tissue engineering applications when compared with poly(l?lactide) alone.Novel biomaterials suitable for bone tissue engineering are currently in demand, and reformulating natural and synthetic biomaterials has caught scientists' attention. Cellulose and collagen have been utilized in biomedical fields. This research aimed to fabricate collagen?cellulose?poly(l?lactide) (Col?Cel?PLL) scaffold using collagen, cellulose, and poly(l?lactide) through electrospinning and radiofrequency plasma treatment and to examine the scaffold's physicochemical and biological properties. Fourier transform infrared spectroscopy revealed its chemistry, and scanning electron microscopy showed fine interconnecting microfibrous fibers; it was super?hydrophilic with low crystallinity (25.59%) and great Young's modulus (163.940?±?8.008?MPa), and it was reasonably degraded. Regarding biological properties, the scaffold was biocompatible by supporting cell attachment and viability. Cells on the Col?Cel?PLL produced high total protein levels and collagen deposition. However, the alkaline phosphatase activity was significantly low.

Publication date: 15/02/2024

Author: Zulka Ziblim, Boontharika Thapsukhon, Vachira Choommongkol, Dheerawan Boonyawan, Kewalin Inthanon, Orawan Khantamat, Jetsada Ruangsuriya

Plasma Processes and Polymers


This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 870292.