Technological watch

Functionalized Polyamine Synthesis with Photoredox Catalysis

Polyamines, such as putrescine and spermidine, are pivotal in various biological processes across living organisms. Despite their significance, structurally modified polyamines offer a less?explored avenue for discovering bioactive compounds. The limitation is attributed to the synthetic difficulty of accessing functionalized polyamines. In this study, we accomplished photoredox?catalyzed functionalization of polyamines to diversify their structure. The rapid functionalization allows attaching fluorophores to the target polyamine, facilitating the development of molecular probes for advancing chemical biology studies.

Publication date: 24/01/2024



This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 870292.