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Synthesis and characterization of photopolymerizable hydrogels based on poly (ethylene glycol) for biomedical applications

AbstractHydrogels are polymeric materials widely used in medicine due to their similarity with the biological components of the body. Hydrogels are biocompatible materials that have the potential to promote cell proliferation and tissue support because of their hydrophilic nature, porous structure, and elastic mechanical properties. In this work, we demonstrate the microwave?assisted synthesis of three molecular weight varieties of poly(ethylene glycol) dimethacrylate (PEGDMA) with different mechanical and thermal properties and the rapid photo of them using 1?hydroxy?cyclohexyl?phenyl?ketone (Irgacure 184) as UV photoinitiator. The effects of the poly(ethylene glycol) molecular weight and degree of acrylation on swelling, mechanical, and rheological properties of hydrogels were investigated. The biodegradability of the PEGDMA hydrogels, as well as the ability to grow and proliferate cells, was examined for its viability as a scaffold in tissue engineering. Altogether, the biomaterial hydrogel properties open the way for applications in the field of regenerative medicine for functional scaffolds and tissues.

Publication date: 20/01/2021

Author: Prutha Joshi, Steven Breaux, Joseph Naro, Yuyang Wang, Md Shakir Uddin Ahmed, Komal Vig, Maria L. Auad

Reference: doi:10.1002/app.50489

Journal of Applied Polymer Science


This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 870292.