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Electrosprayed Seaweed Derived Nanoparticles Loaded with Sensitive Bioagents

By Bhavna KavetiJun 24 2022Reviewed by Susha Cheriyedath, M.Sc.Due to their distinct features, nanomaterials are explored as delivery systems for bioactive agents. In an article recently published in the journal Carbohydrate Polymers, researchers designed D-limonene- κ-carrageenan nanoparticles (DL-κC NPs) through a one-step process. These nanoparticles released the bioactive DL in a pH-dependent manner in vitro. 

Study: Encapsulation of bioactives within electrosprayed κ-carrageenan nanoparticles. Image Credit: Love Employee/

Increasing the κC concentration promoted the photo/thermal stability of DL. In NPs with 0.5% κC, over 85% of original DL was preserved by exposing the NPs to ultraviolet (UV) light for 120 minutes. Through this work, the researchers demonstrated the efficiency of electrosprayed κC NPs in designing high-loaded, pH-sensitive NPs to encapsulate sensitive bioactive agents.

Biological Importance of DL and κCDL is a monocyclic monoterpene, primarily found in citrus essential oil. Despite its benefits to human health, the biomedical application of DL was limited due to its hydrophobicity, oxidative susceptibility, high reactivity, and high volatility.

Encapsulating DL molecules can overcome these challenges. Due to their distinct features like higher surface-area-to-volume ratio, solubility, entrapment efficiency, and bioavailability, nanocarriers can be used for encapsulating potent drug molecules.

Electrospraying is a low-cost nanoencapsulation technique that enables the preparation of nanoparticles for drug or bioactive delivery. It involves the engineering of nanosized particles from polymeric suspensions, solutions or emulsions applied through conductive spinneret by applying high voltage.

κC is a water-soluble polysaccharide obtained from Rhodophyta (red seaweed). It is a nontoxic and biodegradable macroion with excellent solubility in aqueous solvents. Additionally, κC has biomedical applications with anti-tumor, anti-hyperlipidemic, anti-coagulant, antioxidant, immunomodulatory, and anti-viral properties, making it a potent carrier matrix for drugs or bioactive delivery.

κC-based structures are investigated for food and pharmaceutical applications, including drug delivery, food packaging, tissue engineering, and wound healing. Food-grade κC is nontoxic and stable in the gut.

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    Written by

    Bhavna KavetiBhavna Kaveti is a science writer based in Hyderabad, India. She has a Masters in Pharmaceutical Chemistry from Vellore Institute of Technology, India, and a Ph.D. in Organic and Medicinal Chemistry from Universidad de Guanajuato, Mexico. Her research work involved designing and synthesizing heterocycle-based bioactive molecules, where she had exposure to both multistep and multicomponent synthesis. During her doctoral studies, she worked on synthesizing various linked and fused heterocycle-based peptidomimetic molecules that are anticipated to have a bioactive potential for further functionalization. While working on her thesis and research papers, she explored her passion for scientific writing and communications.

    Publication date: 24/06/2022



    This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 870292.