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Deep Learning as a Compass for Industrial Biocatalysis: The Grase Framework Rewrites the Rules for Polyurethane Recycling

Graphical Abstract and Lay SummaryThe GRASE deep?learning framework overcomes the enzyme activity–stability trade?off to discover AbPURase, a robust biocatalyst that efficiently depolymerizes polyurethane waste in harsh industrial conditions, enabling scalable, closed?loop chemical recycling.

Publication date: 04/04/2026

BIOTECHNOLOGY JOURNAL

      

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 870292.