Technological watch

Piezo?bio interaction interfaces are proposed as a conceptual framework to decode the biological effects of piezoelectric nanomaterials through interpreting physicochemical mechanisms at nano?bio interaction interfaces. The vast biological potential of piezoelectric nanomaterials is unveiled, positioning them as distinct nanotools to decipher the electric landscapes of life processes at the nanoscale, while guiding the development of transformative biomedical applications.Piezoelectric nanomaterials are gaining prominence in biomedicine, showing remarkable potential due to their ultrasonic response properties and unique physical and chemical characteristics. However, the core mechanism, especially the interdisciplinary interactions between nanoparticles and cells, is still ambiguous, thus impeding further applications. In this Perspective, the piezo?bio interaction interface is presented as a key for unlocking interaction mechanisms and regulating cellular behaviors. The brief principles of piezoelectricity are summarized, surface electric field and interface engineering, then analyze the underlying interaction mechanisms at the interface from both physical and chemical perspectives. On these basis, a detailed discussion is conducted on how to manipulate biological processes by regulating crucial biomolecules through piezo?bio interaction interfaces. Finally, the beneficial outlooks are presented to enlighten the brand?new applications of piezo?bio interaction interfaces in both fundamental research and biomedical applications. Hopefully, this Perspective can foster the interdisciplinary integration of materials science, physics, chemistry, and biology, further inspiring the advances of piezoelectric nanomaterials in biomedicine.