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Corrosion casting is a technique used to replicate anatomical structures by injecting a polymeric resin into a void space, for example, the circulatory system, and let to solidify. This review highlights the relationship between the technique and the properties of the casting material, considering biological and procedural aspects. This in view of forthcoming research in corrosion casting materials.AbstractCorrosion casting is an important manufacturing technique to replicate anatomical structures. Its execution is often based on the injection of resins that can be polymerized starting at room temperature in the presence of an accelerator, which suits most of the practical requirements. In the present contribution, we highlight the main challenges of the corrosion casting technique, addressing a multidisciplinary research angle connecting the fields of life science, veterinary science, materials science, rheology, and polymer reaction engineering. We pay attention to (commercial) material availability, casting medium selection criteria, specimen preparation, maceration, injection possibilities, cleaning procedures, and detail of replication. We start the discussion from general principles and recommendations to then include major examples for each corrosion casting characteristic addressed.